We are in the midst of a new genomic era, where high-throughput sequencing approaches and genome engineering are revolutionizing research in the biological sciences. These technological advancements promise to revolutionalize our understanding of gene regulation.
Enabled by transcriptome sequencing, novel species of RNA have been found to be abundantly expressed in the nervous systems of animals ranging from fruit flies to humans. These include extended 3' UTR mRNA isoforms (Smibert, Miura et al., 2012; Miura, Shenker et al., 2013) and circular RNAs (Westholm, Miura et al., 2014; Gruner et al., 2016, Cortés-Lopez, 2016).
The mission of the laboratory is to decipher how these newly discovered RNA molecules are regulated and what are their physiological roles in cells, in particular, neurons.